Used APPLIED BIOSYSTEMS / ABI / MDS SCIEX API 4000 #9408909 for sale

APPLIED BIOSYSTEMS / ABI / MDS SCIEX API 4000 (AA 4000) is a high-performance liquid chromatography-mass spectrometry (HPLC-MS) equipment that is designed to help laboratories accurately detect and quantify chemical analytes in samples. It utilizes the principles of tandem mass spectrometry (MS/MS) to reach ultra-high sensitivity and excellent selectivity. The AA 4000 can be used for a large number of small to medium-scale applications, such as small molecule screening, metabolism profiling studies, biomarker discovery, environmental screening, and high-throughput quantitation. The AA 4000 consists of three primary components: a double-focusing high-performance quadrupole mass spectrometer, a high-pressure liquid chromatograph (HPLC), and a sample injector. The high-pressure liquid chromatograph comprises a heated module, columns, pumps, a detector, and data analysis software. The heated module is capable of delivering a range of mobile phases and solvents, while the columns consist of column types tailored to the specific application. The pumps provide accurate flow rate control and polarity switching, while the detector is a single multi-channel array detector (MALDI) capable of simultaneously detecting all mass analytes in the sample. The sample injector is a programmable autosampler capable of injecting up to 16 samples simultaneously, and it includes a sample warming and recovery system to ensure accurate results. The AA 4000 also features a dual-flow mode that utilizes two columns in tandem to maximize sensitivity and selectivity. This dual-flow mode is especially useful for metabolomics studies and for monitoring in-vivo and in-vitro synthesis. The AA 4000 can be operated in several different modes including SIM (selective ion mode), MRM (multiple reaction monitoring), and PRM (product ion mode). In SIM mode, the instrument acquires spectra from the full range of precursor masses to acquire an overview of sample components, while in MRM and PRM modes only specific precursor and product ions are monitored for more quantitative analyses. The AA 4000 is also equipped with a range of other accessories, including an electronic pneumatic control unit, which allows the analyst to configure and automate injections during a run, as well as a quaternary solvent delivery machine, which provides accurate and precise control of mobile phase solvents. The tool also includes a range of software solutions and world-class support to ensure optimal operation and performance. The AA 4000 is a reliable and highly capable HPLC-MS asset that is suitable for a range of small to medium-scale applications.