Used BRUKER timsTOF Pro #293827208 for sale

Name: BRUKER timsTOF Pro
Brand: BRUKER
SKU: 293827208
Availability: InStock

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Spectrometers

Manufacturer

BRUKER

Model

timsTOF Pro

ID: 293827208

Vintage: 2021

Mass spectrometer Integrated with the nanoElute LC System 4D-Omics Workflows Shotgun proteomics, Metabolomics, and Lipidomics Ultra-High Performance Liquid Chromatography (UHPLC) system Nanoelute LC system: High-pressure nanoflow liquid chromatography system Low-void-volume fluidics and torque-limiting fittings Sharp chromatographic peaks Leak-free, Zero-dead-volume connections Trapped Ion Mobility Spectrometry (TIMS): Gas-phase separation technique Collisional Cross-Section (CCS) Quadrupole Time-Of-Flight (QTOF): Mass analyzer designed Deliver high resolution Accurate mass alignment Captive spray ion source: Ionization source optimized Nanoflow eluent LC Mass spectrometer intlet Maximum ionization efficiency PASEF (Parallel Accumulation Serial Fragmentation): Proprietary method synchronizes Quadrupole isolation window Elution times specific peptide packages 100–120 Hz Compromising sensitivity or resolution Dual-tims design: Peptide ions accumulate TIMS tunnel while ions Rear section undergo serial elution Near-100 percent duty cycle Low-abundance precursors Multiple times for high-quality MS/MS spectra MOMA (Mobility Offset Mass Aligned): Isolates isobaric peptides Identical mass-to-charge ratios Differentiated by standard m/z metrics Post-Translational Modification (PTM) Phosphorylated / Unphosphorylated variants High depth and yield: Running a 90-minute gradient Identifies more than 5,000 protein Tiny 200 ng sample HeLa cell digest Short-gradient screenings: Short analytical gradients 30 minutes Comfortably run up to 50 samples Exceptional identification rate 4,000 Protein groups Instrument robustness: Internal geometry focuses ions Enabling continuous, routine operation Complex samples Requiring frequent hardware cleaning Power supply: 230 VAC 50 / 60 Hz 2021 vintage.

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BRUKER timsTOF Pro is a cutting-edge mass spectrometer designed for advanced analytical applications in the fields of proteomics, metabolomics, lipidomics, and other areas of life science research. Leveraging innovative technologies and state-of-the-art features, this instrument offers high sensitivity, ultra-high resolution, and accurate mass measurements, making it a valuable tool for in-depth characterization of complex biological samples. At the core of timsTOF Pro is trapped ion mobility spectrometry (TIMS) coupled with time-of-flight (TOF) mass spectrometry, hence the name 'timsTOF'. TIMS enables the separation of ions based on their collision cross-sections, providing an additional dimension of separation alongside traditional mass spectrometry. This feature allows for enhanced peak capacity, improved selectivity, and increased confidence in compound identification. BRUKER timsTOF Pro features a dual TIMS device that further enhances separation power and resolution. By dynamically accumulating ions in the mobility region before releasing them into the TOF analyzer, the instrument achieves unparalleled resolution and sensitivity, enabling the detection of low-abundance analytes in complex samples. This technology is particularly advantageous for challenging analyses that require the identification of subtle differences in composition or structure. In terms of performance, timsTOF Pro offers ultra-high resolution, with resolving power exceeding 200,000 at full width at half maximum (FWHM). This exceptional resolution enables the differentiation of closely related compounds and the detection of isotopic fine structures, further enhancing the depth and accuracy of analyses. Additionally, the instrument's accurate mass measurements ensure precise determination of molecular weights, facilitating the identification of unknown compounds and elucidation of complex biochemical pathways. One of the key advantages of BRUKER timsTOF Pro is its speed and efficiency in data acquisition. The instrument is capable of acquiring high-resolution MS and MS/MS spectra at ultra-fast scan rates, enabling rapid analysis of complex samples without compromising sensitivity or resolution. This high-speed data acquisition is essential for high-throughput studies and time-sensitive experiments, allowing researchers to process large datasets quickly and efficiently. TimsTOF Pro is also equipped with advanced data processing and analysis software, designed to handle large-scale proteomics and metabolomics datasets. The instrument's software enables seamless data integration, visualization, and interpretation, facilitating the identification of biomarkers, quantification of analytes, and discovery of novel compounds. Furthermore, the system supports data-dependent acquisition (DDA) and data-independent acquisition (DIA) modes, allowing for flexible and comprehensive analysis strategies tailored to the specific research objectives. Overall, BRUKER timsTOF Pro represents a significant advancement in mass spectrometry technology, offering unparalleled sensitivity, resolution, and speed for the analysis of complex biological samples. With its unique combination of TIMS and TOF technologies, coupled with high-performance data processing capabilities, timsTOF Pro is a versatile instrument that empowers researchers to explore new frontiers in proteomics, metabolomics, and beyond.